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| Seneca Valley virus ： ウィキペディア英語版 |
Senecavirus
''Senecavirus'' is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Pig and maybe also cow serve as natural hosts. There is currently only one species in this genus: the type species ''Senecavirus A''.'〔(【引用サイトリンク】url=http://viralzone.expasy.org/all_by_species/697.html )〕〔(【引用サイトリンク】title=Virus Taxonomy: 2014 Release )〕 ''Senecavirus'' is a replication-competent oncolytic picornavirus. It has selective tropism for cancers with neuroendocrine features including small cell lung cancer (SCLC) and several pediatric solid tumors including retinoblastoma, neuroblastoma, and medulloblastoma. A Phase I clinical trial of Senecavirus in adults with neuroendocrine tumors showed that senecavirus is apparently safe to administer at doses up to 1E11 vp/kg.
It has potential antineoplastic activity.〔National Cancer Institute (Definition of Seneca Valley virus-001 ). ''National Cancer Institute'' Retrieved on 2008-10-09.〕
==Structure==
Viruses in Senecavirus are non-enveloped, with icosahedral, spherical, and round geometries, with T=pseudo3 symmetry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 7.3kb in length.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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